BRSK2_ENST00000382179


    BRSK2_ENST00000382179   |   chr11   |   Q8IWQ3-5   |   BRSK2   |   Isoform 5 of Serine/threonine-protein kinase BRSK2   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
Manual instances
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
|701
|751
M
S
P
E
G
H
P
S
R
W
A
R
P
R
R
P
C
I
C
P
S
S
L
C
S
P
R
E
P
R
S
G
P
A
V
G
R
G
G
A
A
H
H
R
V
P
A
G
H
T
P
G
P
Q
L
L
Q
P
H
L
H
L
P
Q
G
Q
T
W
L
C
L
Q
P
S
P
A
G
L
V
K
L
G
V
H
C
V
T
C
Q
K
V
A
I
K
I
V
N
R
E
K
L
S
E
S
V
L
M
K
V
E
R
E
I
A
I
L
K
L
I
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H
P
H
V
L
K
L
H
D
V
Y
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N
K
K
Y
L
Y
L
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L
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G
G
E
L
F
D
Y
L
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K
K
G
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T
P
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A
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F
F
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I
I
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A
L
D
F
C
H
S
H
S
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D
L
K
P
E
N
L
L
L
D
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K
N
N
I
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A
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F
G
M
A
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V
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L
L
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C
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Y
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R
G
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K
Y
D
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A
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V
W
S
C
G
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I
L
F
A
L
L
V
G
A
L
P
F
D
D
D
N
L
R
Q
L
L
E
K
V
K
R
G
V
F
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M
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F
I
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P
D
C
Q
S
L
L
R
G
M
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D
A
A
R
R
L
T
L
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H
I
Q
K
H
I
W
Y
I
G
G
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N
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P
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P
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Q
P
I
P
R
K
V
Q
I
R
S
L
P
S
L
E
D
I
D
P
D
V
L
D
S
M
H
S
L
G
C
F
R
D
R
N
K
L
L
Q
D
L
L
S
E
E
E
N
Q
E
K
M
I
Y
F
L
L
L
D
R
K
E
R
Y
P
S
Q
E
D
E
D
L
P
P
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N
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K
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D
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K
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K
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A
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H
G
Q
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G
A
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G
L
S
T
S
P
L
S
S
P
R
V
T
P
H
P
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G
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L
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T
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K
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N
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T
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P
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T
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K
D
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P
L
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S
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K
A
D
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H
A
F
L
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P
S
L
S
H
S
V
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T
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K
A
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G
P
A
V
F
Q
K
P
V
K
F
Q
V
D
I
T
Y
T
E
G
G
E
A
Q
K
E
N
G
I
Y
S
V
T
F
T
L
L
S
G
P
S
R
R
F
K
R
V
V
E
T
I
Q
A
Q
L
L
S
T
H
D
P
P
A
A
Q
H
L
S
D
T
T
N
C
M
E
M
M
T
G
R
L
S
K
C
D
E
K
N
G
Q
A
A
Q
A
P
S
T
P
A
K
R
S
A
H
G
P
L
G
D
S
A
A
A
G
P
G
P
G
G
D
A
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Y
P
T
G
K
D
T
A
K
M
G
P
P
T
A
R
R
E
Q
P
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
KEN-box
GSK3-improved
Aurora A
CDK1 motif 1 - [ST]Px[KR]x
Nck 2nd SH3
Protein Kinase A
Cdk5 Kinase
Erk1 Kinase
GSK3-improved
GSK3 Kinase
GSK3-improved
GSK3 Kinase
Cdc2 Kinase
GSK3 Kinase
GSK3 Kinase
GSK3-improved
GSK3 Kinase
GSK3-improved
DEG_APCC_DBOX_1
DEG_APCC_DBOX_1
DEG_APCC_DBOX_1
DEG_APCC_KENBOX_2
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1