DTL


    DTL   |   chr1   |   Q9NZJ0   |   DTL   |   Denticleless protein homolog   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Exp disorder
Exp order
Disorder
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Motifs
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
 
|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
|701
M
L
F
N
S
V
L
R
Q
P
Q
L
G
V
L
R
N
G
W
S
S
Q
Y
P
L
Q
S
L
L
T
G
Y
Q
C
S
G
N
D
E
H
T
S
Y
G
E
T
G
V
P
V
P
P
F
G
C
T
F
S
S
A
P
N
M
E
H
V
L
A
V
A
N
E
E
G
F
V
R
L
Y
N
T
E
S
Q
S
F
R
K
K
C
F
K
E
W
M
A
H
W
N
A
V
F
D
L
A
W
V
P
G
E
L
K
L
V
T
A
A
G
D
Q
T
A
K
F
W
D
V
K
A
G
E
L
I
G
T
C
K
G
H
Q
C
S
L
K
S
V
A
F
S
K
F
E
K
A
V
F
C
T
G
G
R
D
G
N
I
M
V
W
D
T
R
C
N
K
K
D
G
F
Y
R
Q
V
N
Q
I
S
G
A
H
N
T
S
D
K
Q
T
P
S
K
P
K
K
K
Q
N
S
K
G
L
A
P
S
V
D
F
Q
Q
S
V
T
V
V
L
F
Q
D
E
N
T
L
V
S
A
G
A
V
D
G
I
I
K
V
W
D
L
R
K
N
Y
T
A
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
S
S
T
R
K
L
G
Y
S
S
L
I
L
D
S
T
G
S
T
L
F
A
N
C
T
D
D
N
I
Y
M
F
N
M
T
G
L
K
T
S
P
V
A
I
F
N
G
H
Q
N
S
T
F
Y
V
K
S
S
L
S
P
D
D
Q
F
L
V
S
G
S
S
D
E
A
A
Y
I
W
K
V
S
T
P
W
Q
P
P
T
V
L
L
G
H
S
Q
E
V
T
S
V
C
W
C
P
S
D
F
T
K
I
A
T
C
S
D
D
N
T
L
K
I
W
R
L
N
R
G
L
E
E
K
P
G
G
D
K
L
S
T
V
G
W
A
S
Q
K
K
K
E
S
R
P
G
L
V
T
V
T
S
S
Q
S
T
P
A
K
A
P
R
A
K
C
N
P
S
N
S
S
P
S
S
A
A
C
A
P
S
C
A
G
D
L
P
L
P
S
N
T
P
T
F
S
I
K
T
S
P
A
K
A
R
S
P
I
N
R
R
G
S
V
S
S
V
S
P
K
P
P
S
S
F
K
M
S
I
R
N
W
V
T
R
T
P
S
S
S
P
P
I
T
P
P
A
S
E
T
K
I
M
S
P
R
K
A
L
I
P
V
S
Q
K
S
S
Q
A
E
A
C
S
E
S
R
N
R
V
K
R
R
L
D
S
S
C
L
E
S
V
K
Q
K
C
V
K
S
C
N
C
V
T
E
L
D
G
Q
V
E
N
L
H
L
D
L
C
C
L
A
G
N
Q
E
D
L
S
K
D
S
L
G
P
T
K
S
S
K
I
E
G
A
G
T
S
I
S
E
P
P
S
P
I
S
P
Y
A
S
E
S
C
G
T
L
P
L
P
L
R
P
C
G
E
G
S
E
M
V
G
K
E
N
S
S
P
E
N
K
N
W
L
L
A
M
A
A
K
R
K
A
E
N
P
S
P
R
S
P
S
S
Q
T
P
N
S
R
R
Q
S
G
K
K
L
P
S
P
V
T
I
T
P
S
S
M
R
K
I
C
T
Y
F
H
R
K
S
Q
E
D
F
C
G
P
E
H
S
T
E
L
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Protein Kinase A
Erk1 Kinase
Erk D-domain
CDK1 motif 1 - [ST]Px[KR]x
GSK3-improved
Erk D-domain
CDK1 motif 2 - [ST]PxxK
GSK3 Kinase
Erk1 Kinase
AMP_Kinase
DEG_APCC_DBOX_1
DEG_APCC_DBOX_1
DEG_APCC_KENBOX_2
DEG_Nend_Nbox_1
DEG_ODPH_VHL_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SPOP_SBC_1
K
K
K
K
K
T
S
Y
K
K
K
S
S
T
T
S
S
S
T
K
S
S
S
S
T
T
S
S
S
S
S
S
S
S
T
S
S
S
T
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
T
S
S
T
T
S
M
S
T
S
S
S
S
T
S
S
S
T
T
DDB1-binding motif
Nuclear localization signal
DDB1-binding motif