EGFR
EGFR | chr7 |
P00533
|
EGFR | Epidermal growth factor receptor |
Sequence
Complexity
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Domains
Structure
Disorder
Motifs
Modifications
Features
Conservation
Position
Significantly mutated
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
ELM instances
Manual instances
Switches
Modification switches
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Regions of interest
Binding regions
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
|701
|751
|801
|851
|901
|951
|1001
|1051
|1101
|1151
|1201
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Recep_L_domain
Furin-like
Recep_L_domain
GF_recep_IV
Pkinase_Tyr
TRG_ENDOCYTIC_2
LIG_PTB_Phospho_1
LIG_PTB_Phospho_1
MOD_N-GLC_2
CBL
LIG_PTB_Phospho_1
LIG_SH2_IE
TRG_ENDOCYTIC_2
LIG_SH2_IE
LIG_SH2_IE
LIG_SH2_III
LIG_SH2_IE
LIG_SH2_ID
LIG_SH2_ID
LIG_TKB
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
S
S
Y
Shc PTB
EGFR Kinase
Erk1 Kinase
Shc PTB
Grb2 SH2
PKC alpha/beta/gamma
p85 SH2
EGFR Kinase
Shc PTB
Insulin Receptor Kinase
DEG_APCC_DBOX_1
DEG_SCF_FBW7_2
DEG_SCF_FBW7_2
Y
Y
Y
S
S
S
S
S
S
S
Y
T
T
T
T
T
T
T
T
T
T
T
Y
T
S
S
S
S
S
S
S
S
T
Y
Y
Y
Y
S
Y
Y
Y
S
S
S
S
S
S
T
S
S
Y
Y
Y
Y
Y
Y
Y
Y
Y
S
S
S
S
S
S
S
S
S
S
Y
Y
Y
Y
T
S
S
Y
Y
Y
Y
S
S
T
T
T
T
T
T
S
S
Y
Y
Y
S
S
S
S
S
S
S
Y
S
S
S
T
S
S
T
S
S
T
S
K
K
S
Y
S
S
T
T
S
T
Y
S
S
Y
S
Y
Y
S
T
Y
Y
T
T
T
S
S
S
Y
K
Y
K
K
S
T
Y
K
S
S
K
K
K
S
Y
S
T
T
T
S
K
K
K
K
S
T
Y
K
K
K
S
K
K
Y
S
S
Y
K
Y
K
K
K
Y
K
Y
T
K
K
T
Y
K
K
Y
S
T
S
Y
S
T
T
S
S
S
Y
Y
S
S
T
S
S
Y
S
S
S
Y
Y
S
Y
Y
R
Important for dimerization, phosphorylation and activation
K
D