MDM2


    MDM2   |   chr12   |   Q00987-11   |   MDM2   |   Isoform 11 of E3 ubiquitin-protein ligase Mdm2   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
ELM instances
Switches
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
M
V
R
S
R
Q
M
C
N
T
N
M
S
V
P
T
D
G
A
V
T
T
S
Q
I
P
A
S
E
Q
E
T
L
V
R
P
K
P
L
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
V
V
N
Q
Q
E
S
S
D
S
G
T
S
V
S
E
N
R
C
H
L
E
G
G
S
D
Q
K
D
L
V
Q
E
L
Q
E
E
K
P
S
S
S
H
L
V
S
R
P
S
T
S
S
R
R
R
A
I
S
E
T
E
E
N
S
D
E
L
S
G
E
R
Q
R
K
R
H
K
S
D
S
I
S
L
S
F
D
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S
L
A
L
C
V
I
R
E
I
C
C
E
R
S
S
S
S
E
S
T
G
T
P
S
N
P
D
L
D
A
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S
E
H
S
G
D
W
L
D
Q
D
S
V
S
D
Q
F
S
V
E
F
E
V
E
S
L
D
S
E
D
Y
S
L
S
E
E
G
Q
E
L
S
D
E
D
D
E
V
Y
Q
V
T
V
Y
Q
A
G
E
S
D
T
D
S
F
E
E
D
P
E
I
S
L
A
D
Y
W
K
C
T
S
C
N
E
M
N
P
P
L
P
S
H
C
N
R
C
W
A
L
R
E
N
W
L
P
E
D
K
G
K
D
K
G
E
I
S
E
K
A
K
L
E
N
S
T
Q
A
E
E
G
F
D
V
P
D
C
K
K
T
I
V
N
D
S
R
E
S
C
V
E
E
N
D
D
K
I
T
Q
A
S
Q
S
Q
E
S
E
D
Y
S
Q
P
S
T
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S
S
I
I
Y
S
S
Q
E
D
V
K
E
F
E
R
E
E
T
Q
D
K
E
E
S
V
E
S
S
L
P
L
N
A
I
E
P
C
V
I
C
Q
G
R
P
K
N
G
C
I
V
H
G
K
T
G
H
L
M
A
C
F
T
C
A
K
K
L
K
K
R
N
K
P
C
P
V
C
R
Q
P
I
Q
M
I
V
L
T
Y
F
P
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DNA PK
PLK1 Kinase
Erk D-domain
Akt Kinase
ATM Kinase
Akt Kinase
DEG_COP1
DEG_SCF_TRCP1_1
DEG_SPOP_SBC_1
DEG_SPOP_SBC_1
DEG_SPOP_SBC_1