MYCN


    MYCN   |   chr2   |   P04198   |   MYCN   |   N-myc proto-oncogene protein   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Significantly mutated
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
Manual instances
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Regions of interest
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
M
P
S
C
S
T
S
T
M
P
G
M
I
C
K
N
P
D
L
E
F
D
S
L
Q
P
C
F
Y
P
D
E
D
D
F
Y
F
G
G
P
D
S
T
P
P
G
E
D
I
W
K
K
F
E
L
L
P
T
P
P
L
S
P
S
R
G
F
A
E
H
S
S
E
P
P
S
W
V
T
E
M
L
L
E
N
E
L
W
G
S
P
A
E
E
D
A
F
G
L
G
G
L
G
G
L
T
P
N
P
V
I
L
Q
D
C
M
W
S
G
F
S
A
R
E
K
L
E
R
A
V
S
E
K
L
Q
H
G
R
G
P
P
T
A
G
S
T
A
Q
S
P
G
A
G
A
A
S
P
A
G
R
G
H
G
G
A
A
G
A
G
R
A
G
A
A
L
P
A
E
L
A
H
P
A
A
E
C
V
D
P
A
V
V
F
P
F
P
V
N
K
R
E
P
A
P
V
P
A
A
P
A
S
A
P
A
A
G
P
A
V
A
S
G
A
G
I
A
A
P
A
G
A
P
G
V
A
P
P
R
P
G
G
R
Q
T
S
G
G
D
H
K
A
L
S
T
S
G
E
D
T
L
S
D
S
D
D
E
D
D
E
E
E
D
E
E
E
E
I
D
V
V
T
V
E
K
R
R
S
S
S
N
T
K
A
V
T
T
F
T
I
T
V
R
P
K
N
A
A
L
G
P
G
R
A
Q
S
S
E
L
I
L
K
R
C
L
P
I
H
Q
Q
H
N
Y
A
A
P
S
P
Y
V
E
S
E
D
A
P
P
Q
K
K
I
K
S
E
A
S
P
R
P
L
K
S
V
I
P
P
K
A
K
S
L
S
P
R
N
S
D
S
E
D
S
E
R
R
R
N
H
N
I
L
E
R
Q
R
R
N
D
L
R
S
S
F
L
T
L
R
D
H
V
P
E
L
V
K
N
E
K
A
A
K
V
V
I
L
K
K
A
T
E
Y
V
H
S
L
Q
A
E
E
H
Q
L
L
L
E
K
E
K
L
Q
A
R
Q
Q
Q
L
L
K
K
I
E
H
A
R
T
C
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DEG_SCF_FBW7_2
GSK3-improved
PLK1 Kinase
Erk1 Kinase
CDK1 motif 1 - [ST]Px[KR]x
Casein Kinase 2
Erk1 Binding
Casein Kinase 2
GSK3 Kinase
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_1
DEG_SCF_FBW7_2
DEG_SPOP_SBC_1
S
S
S
T
T
S
S
S
T
S
S
S
K
S
S
S
S
K
T
S
S
S
S
Leucine-zipper