PLK1


    PLK1   |   chr16   |   P53350   |   PLK1   |   Serine/threonine-protein kinase PLK1   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
ELM instances
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Regions of interest
Binding regions
Motifs
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
M
S
A
A
V
T
A
G
K
L
A
R
A
P
A
D
P
G
K
A
G
V
P
G
V
A
A
P
G
A
P
A
A
A
P
P
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
P
L
T
V
L
N
K
G
L
E
N
P
L
P
E
R
P
R
E
K
E
E
P
V
V
R
E
T
G
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
E
E
A
E
D
P
A
C
I
P
I
F
W
V
S
K
W
V
D
Y
S
D
K
Y
G
L
G
Y
Q
L
C
D
N
S
V
G
V
L
F
N
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
S
H
P
N
S
L
M
K
K
I
T
L
L
K
Y
F
R
N
Y
M
S
E
H
L
L
K
A
G
A
N
I
T
P
R
E
G
D
E
L
A
R
L
P
Y
L
R
T
W
F
R
T
R
S
A
I
I
L
H
L
S
N
G
S
V
Q
I
N
F
F
Q
D
H
T
K
L
I
L
C
P
L
M
A
A
V
T
Y
I
D
E
K
R
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
C
K
E
L
A
S
R
L
R
Y
A
R
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
L
K
A
S
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Protein Kinase A
PKC zeta
PKC mu
AMP_Kinase
DEG_APCC_DBOX_1
DEG_APCC_DBOX_1
DEG_APCC_DBOX_1
T
T
S
T
S
S
S
K
K
K
T
T
Y
S
K
S
Y
S
S
S
S
K
T
K
T
S
S
S
K
S
T
S
Y
T
S
K
K
K
T
S
S
K
S
K
S
K
T
K
K
K
S
T
S
S
T
T
S
S
S
S
T
Activation loop
Linker
Important for interaction with phosphorylated proteins
K
E
D
D-box that targets the protein for proteasomal degradation in anaphase