SH2B1_ENST00000322610


    SH2B1_ENST00000322610   |   chr16   |   Q9NRF2   |   SH2B1   |   SH2B adapter protein 1   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
Manual instances
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Regions of interest
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
|701
|751
M
N
G
A
P
S
P
E
D
G
A
S
P
S
S
P
P
L
P
P
P
P
P
P
S
W
R
E
F
C
E
S
H
A
R
A
A
A
L
D
F
A
R
R
F
R
L
Y
L
A
S
H
P
Q
Y
A
G
P
G
A
E
A
A
F
S
R
R
F
A
E
L
F
L
Q
H
F
E
A
E
V
A
R
A
S
G
S
L
S
P
P
I
L
A
P
L
S
P
G
A
E
I
S
P
H
D
L
S
L
E
S
C
R
V
G
G
P
L
A
V
L
G
P
S
R
S
S
E
D
L
A
G
P
L
P
S
S
V
S
S
S
S
T
T
S
S
K
P
K
L
K
K
R
F
S
L
R
S
V
G
R
S
V
R
G
S
V
R
G
I
L
Q
W
R
G
T
V
D
P
P
S
S
A
G
P
L
E
T
S
S
G
P
P
V
L
G
G
N
S
N
S
N
S
S
G
G
A
G
T
V
G
R
G
L
V
S
D
G
T
S
P
G
E
R
W
T
H
R
F
E
R
L
R
L
S
R
G
G
G
A
L
K
D
G
A
G
M
V
Q
R
E
E
L
L
S
F
M
G
A
E
E
A
A
P
D
P
A
G
V
G
R
G
G
G
V
A
G
P
P
S
G
G
G
G
Q
P
Q
W
Q
K
C
R
L
L
L
R
S
E
G
E
G
G
G
G
S
R
L
E
F
F
V
P
P
K
A
S
R
P
R
L
S
I
P
C
S
S
I
T
D
V
R
T
T
T
A
L
E
M
P
D
R
E
N
T
F
V
V
K
V
E
G
P
S
E
Y
I
M
E
T
V
D
A
Q
H
V
K
A
W
V
S
D
I
Q
E
C
L
S
P
G
P
C
P
A
T
S
P
R
P
M
T
L
P
L
A
P
G
T
S
F
L
T
R
E
N
T
D
S
L
E
L
S
C
L
N
H
S
E
S
L
P
S
Q
D
L
L
L
G
P
S
E
S
N
D
R
L
S
Q
G
A
Y
G
G
L
S
D
R
P
S
A
S
I
S
P
S
S
A
S
I
A
A
S
H
F
D
S
M
E
L
L
P
P
E
L
P
P
R
I
P
I
E
E
G
P
P
T
G
T
V
H
P
L
S
A
P
Y
P
P
L
D
T
P
E
T
A
T
G
S
F
L
F
Q
G
E
P
E
G
G
E
G
D
Q
P
L
S
G
Y
P
W
F
H
G
M
L
S
R
L
K
A
A
Q
L
V
L
T
G
G
T
G
S
H
G
V
F
L
V
R
Q
S
E
T
R
R
G
E
Y
V
L
T
F
N
F
Q
G
K
A
K
H
L
R
L
S
L
N
E
E
G
Q
C
R
V
Q
H
L
W
F
Q
S
I
F
D
M
L
E
H
F
R
V
H
P
I
P
L
E
S
G
G
S
S
D
V
V
L
V
S
Y
V
P
S
S
Q
R
Q
Q
E
P
T
T
S
H
D
P
P
Q
P
P
E
P
P
S
W
T
D
P
P
Q
P
G
A
E
E
A
S
R
A
P
E
V
A
A
A
A
A
A
A
A
K
E
R
Q
E
K
E
K
A
G
G
G
G
V
P
E
E
L
V
P
V
V
E
L
V
P
V
V
E
L
E
E
A
I
A
P
G
S
E
A
Q
G
A
G
S
G
G
D
A
G
V
P
P
M
V
Q
L
Q
Q
S
P
L
G
G
D
G
E
E
G
G
H
P
R
A
I
N
N
Q
Y
S
F
V
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CBL
PKC delta
14-3-3 Mode 1
Aurora B
Src SH3
Aurora A
PKC alpha/beta/gamma
Erk1 Kinase
DNA PK
Abl SH3
Aurora B
Intersectin SH3A
Protein Kinase A
Cortactin SH3
PKC epsilon
DEG_APCC_DBOX_1
DEG_Nend_UBRbox_3
DEG_SPOP_SBC_1
DEG_SPOP_SBC_1
S
S
S
S
S
S
S
S
R
S
S
Y
Y
S
Y
Y
S
S
S
S
S
S
S
S
Y
Y
Interaction with JAK2 (low-affinity binding
Required for self-association
Interaction with RAC1
Required for NGF signaling
Required for nuclear localization