SH2B2


    SH2B2   |   chr7   |   -   |   -   |   -   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
Manual instances
Scansite
Predicted
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
 
|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
M
D
P
S
Y
C
P
A
H
G
F
P
S
Q
D
A
L
W
P
L
S
S
Q
Q
W
S
S
A
H
Y
S
E
P
A
A
G
G
C
D
G
T
E
A
M
N
G
A
G
P
G
P
A
A
A
A
P
V
P
V
P
V
P
V
P
D
W
R
Q
F
C
E
L
H
A
Q
A
A
A
V
D
F
A
H
K
F
C
R
F
L
R
D
N
P
A
Y
D
T
P
D
A
G
A
S
F
S
R
H
F
A
A
N
F
L
D
V
F
G
E
E
V
R
R
V
L
V
A
G
P
T
T
R
G
A
A
V
S
A
E
A
M
E
P
E
L
A
D
T
S
A
L
K
A
A
P
Y
G
H
S
R
S
S
E
D
V
S
T
H
A
A
T
K
A
R
V
R
K
G
F
S
L
R
N
M
S
L
C
V
V
D
G
V
R
D
M
W
H
R
R
A
S
P
E
P
D
A
A
A
A
P
R
T
A
E
P
R
D
K
W
T
R
R
L
R
L
S
R
T
L
A
A
K
V
E
L
V
D
I
Q
R
E
G
A
L
R
F
M
V
A
D
D
A
A
A
G
S
G
G
S
A
Q
W
Q
K
C
R
L
L
L
R
R
A
V
A
E
E
R
F
R
L
E
F
F
V
P
P
K
A
S
R
P
K
V
S
I
P
L
S
A
I
I
E
V
R
T
T
M
P
L
E
M
P
E
K
D
N
T
F
V
L
K
V
E
N
G
A
E
Y
I
L
E
T
I
D
S
L
Q
K
H
S
W
V
A
D
I
Q
G
C
V
D
P
G
L
W
P
G
D
L
E
G
S
W
T
R
S
C
L
H
P
K
R
A
S
E
H
W
E
L
G
R
D
G
S
E
S
P
K
G
W
G
P
G
A
V
A
H
I
C
W
S
R
T
P
D
L
K
R
H
L
S
S
H
I
Y
L
F
V
P
L
S
P
S
P
H
V
P
H
T
V
I
P
T
S
G
E
Q
G
A
E
T
D
P
E
A
E
P
E
L
E
L
S
D
Y
P
W
F
H
G
T
L
S
R
V
K
A
A
Q
L
V
L
A
G
G
P
R
N
H
G
L
F
V
I
R
Q
S
E
T
R
P
G
E
Y
V
L
T
F
N
F
Q
G
K
A
K
A
S
H
L
R
L
S
L
N
G
H
G
Q
C
H
V
Q
H
L
W
F
Q
S
V
L
D
M
L
R
H
F
H
T
H
P
I
P
L
E
S
G
G
S
A
D
I
T
L
R
S
Y
V
R
A
Q
D
P
P
P
E
P
G
P
T
P
P
A
A
P
A
S
P
A
C
W
S
D
S
P
G
Q
H
Y
F
S
S
L
A
A
A
A
C
P
P
A
S
P
S
D
A
A
G
A
S
S
S
S
A
S
S
S
S
A
A
S
G
P
A
P
P
R
P
V
E
G
Q
L
S
A
R
S
R
S
N
S
A
E
R
L
L
E
A
V
A
A
T
A
A
E
E
P
P
E
A
A
P
G
R
A
R
A
V
E
N
Q
Y
S
F
Y
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CBL
GSK3 Kinase
Erk1 Kinase
Akt Kinase
DEG_Nend_UBRbox_2
DEG_SPOP_SBC_1
DEG_SPOP_SBC_1