SPOP


    SPOP   |   chr17   |   O43791   |   SPOP   |   Speckle-type POZ protein   |  

Sequence Complexity Exons OMIM Disease Mutations Polymorphisms Cancer Mutations Domains Structure Disorder Motifs Modifications Features Conservation


Position
Significantly mutated
Sequence
Complexity - SEG
Complexity - DUST
Complexity - TRF
Exons
OMIM Disease Mutations
Polymorphisms
Cancer Mutations
Cancer Indels
Cancer Frameshift/Nonsense
Domains
Structure
Exp disorder
Exp order
Disorder
Scansite
PhosphoElm Modifications
Phosphosite+ Modifications
Uniprot Modifications
Regions of interest
PhastCons
PhyloP
ScoreCons Relevant
ScoreCons All
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|1
|51
|101
|151
|201
|251
|301
|351
M
S
R
V
P
S
P
P
P
P
A
E
M
S
S
G
P
V
A
E
S
W
C
Y
T
Q
I
K
V
V
K
F
S
Y
M
W
T
I
N
N
F
S
F
C
R
E
E
M
G
E
V
I
K
S
S
T
F
S
S
G
A
N
D
K
L
K
W
C
L
R
V
N
P
K
G
L
D
E
E
S
K
D
Y
L
S
L
Y
L
L
L
V
S
C
P
K
S
E
V
R
A
K
F
K
F
S
I
L
N
A
K
G
E
E
T
K
A
M
E
S
Q
R
A
Y
R
F
V
Q
G
K
D
W
G
F
K
K
F
I
R
R
D
F
L
L
D
E
A
N
G
L
L
P
D
D
K
L
T
L
F
C
E
V
S
V
V
Q
D
S
V
N
I
S
G
Q
N
T
M
N
M
V
K
V
P
E
C
R
L
A
D
E
L
G
G
L
W
E
N
S
R
F
T
D
C
C
L
C
V
A
G
Q
E
F
Q
A
H
K
A
I
L
A
A
R
S
P
V
F
S
A
M
F
E
H
E
M
E
E
S
K
K
N
R
V
E
I
N
D
V
E
P
E
V
F
K
E
M
M
C
F
I
Y
T
G
K
A
P
N
L
D
K
M
A
D
D
L
L
A
A
A
D
K
Y
A
L
E
R
L
K
V
M
C
E
D
A
L
C
S
N
L
S
V
E
N
A
A
E
I
L
I
L
A
D
L
H
S
A
D
Q
L
K
T
Q
A
V
D
F
I
N
Y
H
A
S
D
V
L
E
T
S
G
W
K
S
M
V
V
S
H
P
H
L
V
A
E
A
Y
R
S
L
A
S
A
Q
C
P
F
L
G
P
P
R
K
R
L
K
Q
S
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
PIP3-binding PH
K
K
K
Y
S
S
Required for nuclear localization
Important for binding substrate proteins
Important for homodimerization
Important for homodimerization